Lighting, Audio, Light and Sound, Lightsounds for Events, DJ's, Performers, Schools, Venues and Home Parties. Lightsounds has been servicing the Entertainment industry for over 20 years offering reliable and affordable lighting and audio solutions for a large range of event types. You can purchase our products through our website or at one of the Lightsounds store locations. In the three foreign trials, the initial dose of Zofran Injection ranged from 0.04 to 0.87 mg/kg for a total dose of 2.16 to 12 mg. This was followed by the oral administration of ondansetron ranging from 4 to 24 mg daily for 3 days. In the US trial, ZOFRAN was administered intravenously (only) in three doses of 0.15 mg/kg each for a total daily dose of 7.2 to 39 mg. In these trials, 58% of. ZOFRAN ODT (ondansetron) orally disintegrating tablets ZOFRAN (ondansetron hydrochloride) oral solution Initial U.S. Approval: 1991. INDICATIONS AND USAGE ZOFRAN is a 5-HT 3 receptor antagonist indicated for the prevention of: • nausea and vomiting associated with highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m 2. (1) • nausea and vomiting. 16 mg administered 1 hour before induction of anesthesia. Table 2: Pediatric Recommended Dosage Regimen for Prevention of Nausea and Vomiting; Indication. Dosage Regimen. Moderately Emetogenic Cancer Chemotherapy. 12 to 17 years of age: 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent 8-mg dose 8 hours after the first dose. Then administer 8 mg twice a day. Ondansetron is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy), radiation treatment, or drugs used to put you to sleep before surgery.Ondansetron works by blocking one of the body's natural substances that causes vomiting.Ondansetron is available under the following different brand names: Zofran, Zofran ODT, and Zuplenz. Dose: 0.15 mg/kg/dose IV q4h x3 doses; Start: 30min before chemo; Max: 16 mg/dose [PO route, moderately-emetogenic chemo, 4-11 yo] Dose: 4 mg PO q4h x3 doses, then 4 mg PO q8h until 1-2 days after chemo complete; Start: 30min before chemo [PO route, moderately-emetogenic chemo, 12 yo and older].